At present, drying equipment in the pharmaceutical or chemical fields generally has the following problems: ① long drying time, low thermal efficiency, and poor mixing effect; ② The material sticks to the wall and clumps, requiring further processing; ③ Residual equipment materials, cross infection, difficulty in cleaning equipment, and easy contamination of products; ④ Products often experience clumping during drying, where moisture is trapped in hard lumps and cannot achieve good drying results. Installing a crushing knife can effectively solve this problem, while also bringing the benefit of preventing wet materials from getting stuck on the walls of the mixer where they cannot be reached. However, the internal structure of rake drying and cone drying is limited in terms of installing crushing knives In terms of cleaning, due to the fact that the lowest point of the rake drying bottom is a line, the cleaning solution and dissolved products cannot be completely discharged, and there are still many residues, resulting in average GMP compliance. However, due to the narrow bottom space and the vertical installation of the mixing shaft, the bottom area of the conical drying equipment is not within the cleaning range of the spray ball, which brings difficulties in cleaning.

Spherical dryer is a new type of vacuum stirring and drying equipment used in pharmaceutical production. It is a highly engineered and precision processed new equipment that can efficiently mix and dry products in a vacuum state using heat input. Used in the production of pharmaceuticals, chemicals, and flammable and explosive industries. The spherical dryer incorporates the advantages of pressure resistance, large surface area, and no dead corners in the inner cavity of spherical containers into the drying of materials, forming a new type of dryer. However, currently many materials are prone to agglomeration and clumping during the drying process using spherical dryers on the market, resulting in water being trapped in the hard blocks of the material and unable to be effectively dried. The drying effect is not significant and time-consuming.

Changzhou Baide Drying has developed a new type of spherical vacuum dryer to address the problem of many materials being prone to agglomeration and clumping during the drying process, resulting in water being trapped in the hard blocks of the materials and unable to be effectively dried. The drying body is divided into upper and lower spheres, which are connected by hinges. The dryer body is equipped with a crushing device for crushing and granulating the raw materials, a sealing device for the output shaft installed between the upper spheres to prevent material leakage, a filtering device for filtering out the discharge liquid, and a stirring device for stirring and drying mixed reactions. This multifunctional spherical dryer has added a mechanism for crushing and clumping materials, which can obtain materials with relatively uniform particle size, improve drying efficiency, shorten drying time, and obtain materials with uniform particle size.

Working principle of spherical vacuum dryer
Before adding materials, the lower and upper hemispheres are closed by rotating the ball opening and closing device, and the clamp is driven by the oil cylinder to rotate and close the quick lock. Then, the discharge valve is closed. Open the feed valve to inject material, close the feed valve, turn on the heating system, vacuum system, and dry gas sealing system, start the stirring blade and crushing knife, and start the dust removal filter at the same time.
After the material has dried for a certain period of time, open the vacuum sampling valve to extract a small amount of sample to test whether it meets the requirements of the finished product. After the material is dried, close the vacuum system, stop the dust filter and crushing knife, open the vent valve, reduce the speed of the propeller blades appropriately, and finally open the discharge valve to take out the finished product.

Main features of spherical vacuum dryer
The spherical vacuum dryer is developed and designed to meet the requirements of efficient aseptic drying processes, solving the problem of thermal drying. Through the integration of aseptic processes, the entire process of aseptic production is achieved, meeting CGMP requirements. The drying efficiency is the same as that of a fully open dynamic dryer, and the drying is uniform. Less discharge residue and higher CIP efficiency.
(1) The main body of the spherical vacuum dryer is divided into an upper sphere and a lower sphere. The upper and lower spheres are connected by hinges, making it convenient to clean the equipment without dead corners. The special structural design has drying and mixing functions.
(2) Drying efficiency: 2-4 times higher than double cone efficiency, 1.5 times higher than single cone efficiency, 5-10 times higher than oven efficiency, without clumping or pilling, meeting CGMP requirements.
(3) Efficient aseptic drying: The entire drying process does not contaminate materials or be contaminated by external factors, meeting CGMP requirements.
(4) Fully enclosed process docking: Fully enclosed docking with separation equipment, crushing, and subcontracting equipment to achieve aseptic production.
(5) Widely used: drying of pharmaceutical intermediates, active pharmaceutical ingredients, sterile powders, and other food and chemical powders and materials, and also has good effects on the preparation of dry powder from mother liquor.
(6) Intelligent control system: automatic control cabinet, explosion-proof operation box, realizing forward and reverse rotation, interval delay, stepless speed regulation, automatic discharge, and can realize PLC program control.

Technical improvement of spherical vacuum dryer
(1) The spherical vacuum dryer reduces material agglomeration, making the material particles finer and more uniform, and making it easier for moisture to evaporate, thereby improving the drying effect, significantly increasing drying efficiency, and shortening drying time;
(2) The new type of mixing blade and crushing knife both adopt a detachable form, which is also convenient for cleaning and maintenance; The mixing effect of three leaves is excellent; Large volume and high efficiency; Mix evenly without any dead corners; High speed crushing to reduce clumping;
(3) Mix evenly without any dead corners
The stirring force and direction of spherical drying are consistent in all directions, so the mixing is symmetrical and the mixing effect is good. However, the radial and axial mixing of rake drying and cone drying is uneven, and there are dead corners at the edges, which can easily lead to problems with the uniformity of the mixed product.
(4) Quick and easy cleaning
The structure of spherical drying is very simple, and its container is spherical, so it is symmetrical in three directions from the center to the ball wall. In theory, as long as a spray ball is set at the center of the ball, all positions of the dryer can be cleaned. In practice, only 2-3 spray balls are needed for online cleaning and sterilization.
(5) The dust removal filter adopts a high-pressure blowback structure, and there is basically no material loss.
(6) Can be fully opened for easy inspection
The top driven spherical dryer can be easily opened by rotating the lower half of the sphere, allowing for quick inspection at any time; This operation can be easily achieved by tapping the button and using the hydraulic rotary actuator to open the quick lock.
(7) The dust removal filter adopts a high-pressure blowback structure, and there is basically no material loss.
(8) The new type of mixing shaft is inclined and the discharge valve is vertically set, utilizing the gravity of the material to achieve smoother discharge.

Technical parameter table of spherical vacuum dryer

Photo of spherical vacuum dryer equipment